Role of drug transporters and metabolizing enzymes in pharmacokinetics of antibiotics
10.7501/j.issn.1674-6376.2017.09.002
- VernacularTitle:药物转运体和代谢酶在抗生素药动学中的作用
- Author:
na Yan ZHU
1
;
xin Ke LIU
Author Information
1. 大连医科大学药学院临床药理教研室
- Keywords:
drug transporter;
antibiotics;
pharmacokinetics;
metabolizing enzymes
- From:
Drug Evaluation Research
2017;40(9):1197-1202
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,the research on drag transporters has made great progress,more and more transporters have been found and studied,and they have shown important roles in the transport of drug across the cellular membrane.Various transporters,including uptake transporters and effiux transporters,have important effects on the pharmacokinetics and drug-drug interactions.Studies have shown that the process in vivo of most of the antibiotics was related to transporters and metabolizing enzymes (cytochrome P450 and CYP450).Therefore,this article summarized the latest research progress in pharmacokinetics and drug-drug interactions of transporters and CYP450,so that provides evidence for clinical rational use of antibiotics.
