Role of hepatic transporters and metabolic enzymes in chemical substances-induced liver injury
10.7501/j.issn.1674-6376.2017.09.003
- VernacularTitle:肝脏转运体和代谢酶在化学性肝损伤中的作用
- Author:
qing Chen NING
1
;
Qiang MENG
;
xin Ke LIU
Author Information
1. 大连医科大学药学院临床药理教研室
- Keywords:
hepatic transporters;
metabolic enzymes;
chemical substances-induced liver injury
- From:
Drug Evaluation Research
2017;40(9):1203-1209
- CountryChina
- Language:Chinese
-
Abstract:
Liver is an important metabolic and detoxification organ in the body.Hepatic transporters are a series of functional membrane proteins that are extensively expressed in the liver.They are responsible for the uptake of endogenous and exogenous substances such as medicines into hepatocytes and excretion of their metabolic products into bile.Recent studies have provided that transporters and metabolic enzymes play important roles in the chemical substances-induced liver injury,and its various regulatory mechanisms have become hot topics of research.In this paper,we summarize the classification of hepatic transporters and metabolic enzymes and the changes of transporters and metabolic enzymes in the chemical substances-induced liver injury and its regulatory mechanism.
