Mechanism of hepatic transporters and metabolic enzymes in cholestatic liver injury
10.7501/j.issn.1674-6376.2017.09.004
- VernacularTitle:转运体和代谢酶在胆汁淤积性肝损伤中的作用机制
- Author:
guang Xiao GAO
1
;
xin Ke LIU
;
Qiang MENG
Author Information
1. 大连医科大学药学院临床药理教研室
- Keywords:
transporters;
metabolic enzymes;
cholestatic liver injury;
nuclear receptor
- From:
Drug Evaluation Research
2017;40(9):1210-1215
- CountryChina
- Language:Chinese
-
Abstract:
Cholestatic liver injury,which is mainly caused by the disruption of bile acids,is common in the clinic.The pathogenesis of cholestatic liver injury is directly related to the changes of bile acid-related transporters,synthetic and metabolic enzymes.Nuclear receptors play a crucial part in cholestatic liver injury by regulating the expression of transporters and metabolic enzymes that maintaining the homeostasis of bile acids.In this review,we focus on the role of hepatic transporters and metabolic enzymes in cholestatic liver injury and the mechanism of nuclear receptors on the regulation of transporters and metabolic enzymes.
