Vital role of transporters in renal drug elimination
10.7501/j.issn.1674-6376.2017.09.005
- VernacularTitle:转运体在药物肾脏排泄中的重要作用
- Author:
jie Shi WEN
1
;
xin Ke LIU
Author Information
1. 大连医科大学药学院临床药理教研室
- Keywords:
transporters;
kidney;
renal excretion;
pharmacokinetics;
drug-drug interaction
- From:
Drug Evaluation Research
2017;40(9):1216-1222
- CountryChina
- Language:Chinese
-
Abstract:
Transporters are a class of functional membrane proteins which are broadly expressed in the kidney and play a vital role in the reabsorption and secretion of many endogenous and xenobiotic compounds by the kidney.The renal proximal tubule is the primary site of transporter-mediated active transport for many drugs,including organic anion drugs,organic cation drugs and peptide drugs.Transporter-mediated drug-drug interactions may occur in the kidney when some drugs are co-administration.In this review,we focus on the location and function of major transporters in the kidney and summarize their vital role in renal drug elimination.
