Vital role of oligopeptide transporters in physiology and drug transport and their clinical relevance
10.7501/j.issn.1674-6376.2017.09.001
- VernacularTitle:寡肽转运体在生理、药物转运的重要作用及临床相关性
- Author:
Rong SHU
1
;
xin Ke LIU
Author Information
1. 大连医科大学药学院临床药理教研室
- Keywords:
oligopeptide transporters;
localization-expression;
function
- From:
Drug Evaluation Research
2017;40(9):1189-1196
- CountryChina
- Language:Chinese
-
Abstract:
The oligopeptide transporters (PEPTs),including PEPT1 and PEPT2,belong to the SLC family and are driven by H+ gradient.PEPT1,the low-affinity and high-capacity transporter,is mainly expressed in small intestine,whereas PEPT2,the high-affinity and low-capacity transporter,is mainly expressed in kidney,brain and lung and has a broader distribution in the organism.The PEPTs are responsible for the absorption and conservation of dietary protein digestion products in intestine and kidney,respectively,and in maintaining homeostasis of neuropeptides in brain.They are also responsible for the absorption and disposition of a number of pharmacologically important compounds including some aminocephalosporins,angiotensin-converting enzyme inhibitors,antiviral prodrugs and others.And PEPTs are also associated with some intestinal diseases and cancer.Therefore,this article summarizes the important role of PEPTs in physiology and drug transport and their clinical relevance.
