Progress in effects of rhein on drug transporters and metabolic enzymes
10.7501/j.issn.1674-6376.2017.09.006
- VernacularTitle:大黄酸对药物转运体和代谢酶影响的研究进展
- Author:
ci Tian BU
1
;
hao Zhi LIU
;
xin Ke LIU
Author Information
1. 大连医科大学药学院临床药理教研室
- Keywords:
transporter;
metabolic enzyme;
rhein;
drug-drug interaction
- From:
Drug Evaluation Research
2017;40(9):1223-1228
- CountryChina
- Language:Chinese
-
Abstract:
Drug transporters and drag metabolic enzymes are crucial factors in the process of drug treatment.Rhein,as the main active component of traditional Chinese medicine rhubarb,has a wide range of pharmacological activities.Previous studies have shown that rhein is closely related to drug transporters and metabolic enzymes,and can directly activate or inhibit the functions of a variety of transporters and their protein expression.Furthermore,rhein can inhibit the function and protein expression of cytochrome P450 (CYP450),a drug metabolizing enzyme.Thus,when rhein is combined with other drugs,the drug-drug interaction (DDI) may occur based on pharmacokinetic.This paper focuses on the distribution of drug transporters,metabolic enzymes,and the effects of rhein on transporters and metabolic enzymes.
