Research progress on regulation mechanism of epigenetic modifications for drug transporters
10.7501/j.issn.1674-6376.2017.09.007
- VernacularTitle:药物转运体表观遗传调控机制的研究进展
- Author:
lei Shi YANG
1
;
xin Ke LIU
Author Information
1. 大连医科大学药学院临床药理教研室
- Keywords:
drug transporters;
epigenetic modifications;
DNA methylation;
histone modification;
microRNA
- From:
Drug Evaluation Research
2017;40(9):1229-1234
- CountryChina
- Language:Chinese
-
Abstract:
Drug transporters play a key role in drug absorption,distribution and excretion.The distribution and expression of transporters in tissues and organs are regulated by epigenetic modifications,resulting in individual differences of drugs disposition significantly.With the development of epigenetics,researches on the regulation of drug transporters expression based on epigenetic modifications (DNA methylation,histone modification,microRNA interference,etc.) have been more and more reported.In this paper,we will summarize the epigenetic modifications regulating drug transporters.
