Effect of Enteral and Parenteral Nutrition on Body Composition and Disease Activity in Patients With Severe Crohn's Disease
10.3969/j.issn.1008-7125.2017.11.005
- VernacularTitle:肠内外营养对重度克罗恩病患者身体成分和疾病活动性的影响
- Author:
Yamei CHEN
1
;
Yi WANG
;
Chunhua JIANG
;
Shuangshuang XIONG
;
Zhanju LIU
Author Information
1. 上海市第十人民医院消化科 200072
- Keywords:
Enteral Nutrition;
Parenteral Nutrition;
Crohn Disease;
Malnutrition;
Body Composition;
Disease Activity
- From:Chinese Journal of Gastroenterology
2017;22(11):662-665
- CountryChina
- Language:Chinese
-
Abstract:
Background:Malnutrition is common in inflammatory bowel disease,especially in Crohn' s disease (CD).Combined partial enteral and parenteral nutrition is effective for nutritional support in patients with severe CD.Aims:To investigate the effect of combined enteral and parenteral nutritional support on body composition and disease activity in severe active CD patients.Methods:A total of 72 patients with severe active CD admitted from July 2015 to August 2016 at Shanghai Tenth People' s Hospital were enrolled.In addition to conventional antibacterial and remission induction therapy,a combined partial enteral and parenteral nutritional support was given after admission.The nutritional status,body composition parameters and disease activity were evaluated and compared on admission and week 1,week 2 and week 3 of hospitalization.Results:The malnutrition rate was 100％ on admission,of which 90.3％ were severe malnutrition.After a 3-week combined enteral and parenteral nutritional support,the proportion of severe malnutrition decreased from 90.3％ to 34.7％ (P ＜0.05).Meanwhile,the body weight,body mass index,muscle mass,fat mass,protein content,and basal metabolic rate gradually increased and the disease activity index gradually decreased (P all ＜ 0.05).Conclusions:Combined enteral and parenteral nutritional support can improve the nutritional status and body composition parameters,reduce disease activity and induce remission effectively in severe active CD patients.
