Safety pharmacology research on Dexibuprofen injection
10.7501/j.issn.1674-6376.2017.09.013
- VernacularTitle:右旋布洛芬注射液安全药理学研究
- Author:
yong Zhi ZHENG
1
;
Yong YING
;
Kai CHEN
Author Information
1. 山东省药学科学院山东省化学药物重点实验室
- Keywords:
Dexibuprofen injection;
safety pharmacology;
central nervous system;
cardiovascular system;
respiratory system
- From:
Drug Evaluation Research
2017;40(9):1265-1269
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of Dexibuprofen injection on the central nervous,cardiovascular and respiratory systems in animals.Methods The effect of Dexibuprofen injection on central nervous system was observed by autonomic activities experiment,mice concordant ability experiment and hypnotize experiment induced by pentobarbital.The effects of Dexibuprofen injection on circulatory system and respiratory system were observed by measuring the implanted telemetry system,blood pressure,ECG;respiratory rate and tidal volume of Beagle's dogs.Results Dexibuprofen injection (80 mg/kg) showed synergistic action with pentobarbital,and no significant effects on autonomic activities and concordant ability at doses of 20,40 and 80 mg/kg in mice.Dexibuprofen injection at doses of 10,20 and 40 mg/kg had no effect on the central nervous,cardiovascular and respiratory systems.In the same dose,the adverse reaction of Dexibuprofen injection was not increased compared with Ibuprofen injection.Conclusion Dexibuprofen injection (mice 40 mg/kg,dog 40 mg/kg) has none toxicity on cardiovascular,respiratory and central nervous systems,but at the dose of 80 mg/kg in mice has obvious effect on central nervous system.
