Effect of dexmedetomidine combined with sevoflurane on postoperative sedation for children undergoing ophthalmic operation
10.7501/j.issn.1674-6376.2017.09.020
- VernacularTitle:盐酸右美托咪定联合七氟烷对小儿眼科手术术后镇静的影响
- Author:
bo Hua HU
1
;
Li XIE
;
fu Zhi CHEN
Author Information
1. 安康市中医医院麻醉科
- Keywords:
dexmedetomidine;
sevoflurane;
pediatric;
ophthalmic operation;
postoperative sedation
- From:
Drug Evaluation Research
2017;40(9):1297-1301
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of dexmedetomidine combined with sevoflurane on the postoperative sedation for children undergoing ophthalmic operation.Methods Pediatric patients (200 cases) in Ankang Hospital of Traditional Chinese Medicine from January 2014 to August 2016 were enrolled,of which patients were divided into two groups randomly,Group A (n =100) accepted sevoflurane combined with normal saline,and Group B (n =100) adopted sevoflurane combined with dexmedetomidine.The operative conditions and postoperative VAS,Ramsay and PEAD scores were evaluated,and the postoperative adverse reactions were recorded and analyzed.Results There was no significance of the operation time between two groups,the wakened time of Group B was later than that of Group A significantly (P ＜ 0.05),the postoperative extubation quality score of Group B was lower than that in Group A (P ＜ 0.05),and the times of using analgesic in Group B was fewer than that of Group A (P ＜ 0.05);The VAS score of patients in Group B was significantly lower than that of Group A at the time points of T1,T2 and T3;At the time points ofT1 and T2,the Ramsay score of patients in Group B was higher than that in Group A,and PAED score of Group B was lower than that in Group A,with significant difference between Groups A and B (P ＜ 0.05);The incidence of nausea and vomiting,respiratory depression,postoperative agitation of patients in Group B was lower significantly than that of Group A,and the incidence of total adverse reactions in Group B was also lower than that in Group A significantly (P ＜ 0.05).Conclusion The clinical efficacy and safety of dexmedetomidine combined with sevoflurane for patients undergoing ophthalmic operation are remarkable and deserve popularization in clinic,which not only relieves the restlessness agitation of patients in recovery period,but also decreases the incidence of adverse reactions.
