The activity and functional activity effect of sulfasalazine enteric coated tablets combined with thalidomide in the treatment of ankylosing spondylitis patients
10.7501/j.issn.1674-6376.2017.10.024
- VernacularTitle:沙利度胺联合柳氮磺吡啶治疗强直性脊柱炎的疗效观察
- Author:
ming Xue SUN
1
;
Lei LIU
;
jun Jun CAO
;
cui Shan ZHENG
;
Jia TANG
Author Information
1. 昆山市第一人民医院老年医学科
- Keywords:
Sulfasalazine enteric coated tablets;
ankylosing spondylitis;
lumbar spine;
bone mineral density;
alendronate
- From:
Drug Evaluation Research
2017;40(10):1477-1480
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of sulfasalazine enteric coated tablets combined with thalidomide in the treatment of ankylosing spondylitis disease activity and functional activities.Methods From January 2013 to December 2015,60 ankylosing spondylitis patients in our hospital were selected as the research object and were randomly divided into observation group and control group with 30 patients in each group,the control group was given sulfasalazine treatment,the observation group was received thalidomide enteric coated tablets treatment based on the treatment in control group,two groups were treated for 3 months.Results All patients were completed and treatment,and there were no serious adverse reactions occurred during the treatment,the total effective rates of observation group and control group were 96.7％ and 83.3％ respectively,the total effective rate of observation group was significantly higher than that of control group (P ＜ 0.05).The spinal mobility in the observation group and the control group after treatment were (51.34 ± 11.94)° and (43.14 ±9.34)°,that were significantly higher than before treatment of (30.42 ± 13.98)° and (30.45 ± 12.87)° (P ＜ 0.05),and the observation group after treatment of spinal activity was significantly higher than the control group (P ＜ 0.05).The lumbar bone mineral density of the observation group and control group were-0.59 ± 0.32 and-0.89 ± 0.13,which were significantly higher than before treatment (-1.21 ± 0.11 and 1.29 ± 0.15),while after treatment the observation group was higher than the control group (P ＜ 0.05).Conclusion Sulfasalazine enteric coated tablets in the treatment of ankylosing spondylitis has good safety,it can promote the bone mineral density of lumbar spine recovery,improve the spinal mobility,so as to improve the curative effect.
