Research progress of hepatotoxicity mechanism and attenuation of Tripterygium wilfordii glycoside
10.7501/j.issn.1674-6376.2017.10.030
- VernacularTitle:雷公藤多苷肝毒性发生机制及减毒相关研究进展
- Author:
Lan LUO
1
;
zhou Zhen JIANG
;
yong Lu ZHANG
Author Information
1. 中国药科大学江苏省新药筛选重点实验室
- Keywords:
Tripterygium wilfordii glycoside;
adverse reaction;
hepatotoxicity mechanism;
material base;
attenuated drug
- From:
Drug Evaluation Research
2017;40(10):1504-1509
- CountryChina
- Language:Chinese
-
Abstract:
Tripterygium wilfordii glycoside is an effective component extracted from Tripterygium wilfordii Hook.F.It has an effect on immunosuppression and anti-inflammatory which is used to treatments of rheumatic arthritis and nephrotic syndrome on clinic.The liver adverse reactions have been particularly significant in Tripterygium wilfordii glycoside induced adverse reactions.The aim of this article is to summarize the research of hepatotoxicity mechanism of Tripterygium wilfordii glycoside in recent ten years,to analyze toxic material base,and to search for the attenuated drugs and mechanism.For the clinical application of Tripterygium wilfordii glycoside this article provides related literature and theoretical basis research.
