Research progress on vascular pharmacologic effects of oleanolic and ursolic acids
10.7501/j.issn.1674-6376.2017.10.031
- VernacularTitle:熊果酸和齐墩果酸的血管药理作用研究进展
- Author:
fa Ming ZHANG
1
;
qin Ya SHEN
Author Information
1. 上海美优制药有限公司
- Keywords:
ursolic acid;
oleanolic acid;
endothelial cells;
vascular smooth muscle cells;
vascular stenosis;
angiogenesis;
vascular relaxation
- From:
Drug Evaluation Research
2017;40(10):1510-1519
- CountryChina
- Language:Chinese
-
Abstract:
Ursolic and oleanolic acids antagonize ox-LDL-,C-reactive protein-,non-enzymatic glycation end products-,hyper-glucose-,H2O2-,lipopolysaccharide-induced endothelial cell injury,and their vascular pharmacologic effects are in many ways.Ursolic and oleanolic acids can inhibit the proliferation of vascular smooth muscle cells,and antagonize serum-,ox-LDL-,hyper-glucose-,leptin-induced vascular smooth muscle cell proliferation,thus produce vascular protection and improve vascular function;Ursolic and oleanolic acids can relieve diabetic vascular complication in diabetic mellitus rats,and vascular stenosis induced by carotid balloon catheter injury,and suppress the proliferation of vascular adventitial fibroblasts and prevent vascular stenosis induced by various experimental atherosclerosis models;they can also inhibit the proliferation of vascular endothelial cells,and have a dual action to antagonize inhibiting or promoting proliferation induced by various injurious factions.Thus they have a dual role of regulation in angiogenesis,and suppress angiogenesis of cornea,diabetic retina,and tumor tissues,have effects of vascular relaxation and resistance decrease,and have hypotensive effects in normal and various hypertensive animals.
