Effects of atorvastatin on serum levels of inflammatory factors, pulmonary function and right ventricular remodeling in patients with chronic obstructive pulmonary disease complicated with pulmonary hypertension
10.7501/j.issn.1674-6376.2017.09.026
- VernacularTitle:阿托伐他汀对慢性阻塞性肺疾病合并肺动脉高压患者血清炎症因子水平、肺功能及右心室重塑的影响
- Author:
jun Long MAO
1
;
Ying LI
;
Hua QIANG
Author Information
1. 宝鸡市中心医院老年心脑血管病科
- Keywords:
chronic obstructive pulmonary disease;
pulmonary hypertension;
serum inflammatory factors;
right ventricular remodeling
- From:
Drug Evaluation Research
2017;40(9):1323-1326
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of atorvastatin on serum levels of inflammatory cytokines,pulmonary function and right ventricular remodeling in patients with chronic obstructive pulmonary disease (COPD) complicated with pulmonary hypertension.Methods From December 2013 to December 2016,106 patients with COPD complicated with pulmonary hypertension were randomly divided into treatment and control groups,each with 53 cases.Patients in control group were treated with routine basic therapy for three months,and patients in treatment group were treated with atorvastatin on the basis of control group.The pulmonary function,right ventricular remodeling function and inflammatory factors were detected,and the clinical efficacy of two groups was evaluated.Results The total effective rate was 94.34％ in the treatment group and 79.25％ in the control group,difference between the two groups was significant (P ＜ 0.05).The levels of FEV1 and FVC were not significantly different between two groups before treatment.The levels of FVC and FEV1 in treatment group were significantly higher than those in the control group after treatment (P ＜ 0.05).After treatment,the LVED,LVPW,TRVmax and RVEF of treatment group were significantly higher than those of control group (P ＜ 0.05),and the difference was statistically significant.Compared with before treatment,LVID,LVPW and TRVmax were increased,RVAD decreased,and the difference was statistically significant (P ＜ 0.05).The levels of CRP,ET and IL-6 in the treatment group were significantly lower than those in the control group (P ＜ 0.05),and difference was statistically significant.Conclusion The effect of atorvastatin on serum inflammatory factors,pulmonary function and right ventricular remodeling in patients with COPD combined with pulmonary hypertension is significant and can be popularized.
