Effect of citalopram hydrobromide tablets on cognitive function and inflammatory factors in patients with recurrent bipolar disorder
10.7501/j.issn.1674-6376.2017.11.021
- VernacularTitle:西酞普兰联合丙戊酸钠对复发双相障碍抑郁发作患者认知功能及血清炎症因子的影响
- Author:
Xiao LIU
1
;
bin Rui YAN
;
Jin LI
Author Information
1. 青海省人民医院
- Keywords:
bipolar disorder;
citalopram hydrobromide;
cognitive function;
inflammatory factors
- From:
Drug Evaluation Research
2017;40(11):1631-1634
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of citalopram hydrobromide tablets on cognitive function and inflammatory factors in patients with recurrent bipolar disorder (BPD),and to analyze its possible mechanism of action.Methods 104 patients with recurrent BPD in our hospital from July 2014 to December 2015 were selected,and they were divided into observation group and control group by random number table,52 cases in each group.Control group was given sodium valproate,while observation group was given citalopram hydrobromide tablets and sodium valproate.After 8-week treatment,the emotional state,cognitive function,inflammatory factors were compared between the two groups.Results Before treatment,HAMD score,BPMS score of two groups were not statistically significant.After 8 weeks of treatment,HAMD score and BPMS score of two groups were significantly lower than those in the same group before treatment (P ＜ 0.01);and the observation group HAMD score and BPMS score were significantly lower than the control group (P ＜ 0.01).Before treatment,TMT-A,TMT-B time of two groups were not statistically significant.After 8 weeks of treatment,TMT-A and TMT-B time of two groups were significantly shorter than the same group before treatment (P ＜ 0.05).TMT-A TMT-B in the observation group were significantly shorter than the control group (P ＜ 0.05).The content of serum MIF,IL-1 beta and IL-6 in two groups before treatment were not statistically significant.After 8 weeks of treatment,the contents ofMIF,IL-1 beta,IL-6 in two groups were significantly lower than the same group before treatment (P ＜ 0.05).And the levels of serum MIF,IL-1 beta,IL-6 in observation group were significantly lower than the control group (P ＜ 0.05).Conclusion Citalopram hydrobromide tablets can relieve clinical symptoms,improve cognitive function,and it possibly has relations with inhibiting the expression of inflammatory factors.
