Research advance on pharmacokinetics of oleanolic acid
10.7501/j.issn.1674-6376.2017.11.028
- VernacularTitle:齐墩果酸的药动学研究进展
- Author:
fa Ming ZHANG
1
;
qin Ya SHEN
Author Information
1. 上海美优制药有限公司
- Keywords:
oleanolic acid;
pharmacokinetics;
pharmacologic effect;
rational use of drug
- From:
Drug Evaluation Research
2017;40(11):1664-1670
- CountryChina
- Language:Chinese
-
Abstract:
Oleanolic acid has a widespread pharmacologic effect,including anti-inflammation,antitumor,anfidiabetes,anti-atherosclerosis,hepatoprotection,anti-osteoporosis,etc.Bioavailability of oleanolic acid by oral administration is low,and is absorbed by intestine through passive transport.Oleanolic acid dispersion preparation can increase its solubility and bioavailability,and concentrate on liver to help treat for hepatic disease.The pharmacokinetic parameters,process in body of oleanolic acid,and the pharmacokinetic feature of oleanolic acid dispersion and its prodrug are reviewed,and its research advance on pharmacokinetics is summarized,which provides a reference for rational utilization of oleanolic acid.
