Research progress of three long-acting basic insulin analogues
10.7501/j.issn.1674-6376.2017.11.029
- VernacularTitle:三种长效基础胰岛素类似物的研究进展
- Author:
yan Xing ZHANG
1
;
zhuo Ya LI
;
Yong ZENG
;
Jun LI
;
lin Xiu YI
Author Information
1. 安徽医科大学药学院抗炎免疫药物教育部重点实验室
- Keywords:
diabetes;
long-acting basic insulin;
insulin glargine;
insulin detemir;
insulin degludec
- From:
Drug Evaluation Research
2017;40(11):1671-1676
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes is a kind of worldwide chronic disease with high incidence,which threatens people's lives and work.With the development of DNA recombination technology,long-acting basal insulin analogues bring gospel and hope for patients with diabetes.Insulin glargine (IGla),detemir (IDet) and degludec (IDeg),as three basic types of insulin,commonly used in clinical practice that slowly absorbed and distributed by changing the structure,and relatively long acting time,more fit the physiological model of insulin secretion.Therefore,the existing studies of molecular structure,long-acting mechanism,safety evaluation and pharmacodynamic effects of three kinds of insulin preparations are briefly summarized.
