Detection and analysis on serum antibodies for five common pathogenic microbes in patients with Posner-Schlossmarm syndrome
10.3760/cma.j.issn.2095-0160.2017.12.012
- VernacularTitle:青光眼睫状体炎综合征患者5种常见病原微生物相关血清抗体的测定及分析
- Author:
Wenchieh CHEN
1
;
Jun ZHAO
;
Tianhui ZHU
;
Shiming PENG
;
Xiaosheng HUANG
;
Shaoyi MEI
;
Yan WANG
Author Information
1. 518040,深圳市眼科医院 暨南大学附属深圳眼科医院 深圳眼科学重点实验室
- Keywords:
Posner-Schlossman syndrome;
Etiology;
Cytomegalovirus;
Herpes simplex virus;
Rubella virus;
Helicobacter pylori;
Anti-streptolysin O;
Antibody
- From:
Chinese Journal of Experimental Ophthalmology
2017;35(12):1115-1119
- CountryChina
- Language:Chinese
-
Abstract:
Background Posner-Schlossman syndrome (PSS) is often recurrent and is a cause of blindness.The etiology of PSS remains to be elucidated.It is reported that there is a certain association between pathogenic microorganisms and PSS in rather small samples.Objective This study was to analyze the related serum antibody levels of cytornegalovirus (CMV),herpes simplex virus (HSV),rubella virus (RV),helicobacter pylori (HP) and anti-streptolysin O (ASO) and provide a clue for the study on pathogenesis and therapy of PSS.Methods A prospective cases-controlled study was carried out in Shenzhen Eye Hospital from December,2014 to December,2016 under the approval of Ethic Committee of this hospital and informed consent of each subject prior to initial of any medical examination.Peripheral blood samples were collected from 82 PSS patients as the PSS group and 100 age-and gender-matched healthy blood donors as the normal control group.The positive rates of serum CMV IgG,CMV IgM,HSV IgG,HSV IgM,RV IgG,RV IgM,HP IgG and HP IgM in the subjects were detected by indirect ELISA,and the positive rate of serum ASO antibody was determined by immuno-scatter turbidmetry.Results The positive rates of serum CMV-IgG,CMV-IgM,HP-IgG,HP-IgM and ASO antibody were 22.0％,17.1％,22.0％,17.1％ and 17.1％ in the PSS group,which were significantly higher than 5.0％,0.0％,10.0％,2.0％ and 7.0％ in the normal control group (x2 =11.726,18.496,4.943,12.766,4.479,all at P＜0.05).The positive rates of serum HSV-IgG,HSV-IgM,RV-IgG and RV-IgM in the PSS group were not significantly different from those in the normal control group (x2 =3.305,0.986,0.898,0.503,all at P ＞ 0.05).Conclusions CMV,HP and hemolytic streptococcal infection may participate in the occurrence and development of PSS.
