Application of RNA interference in posterior capsule opacification by interfering signaling pathway

VernacularTitle:RNA干扰技术干扰信号通路在后发性白内障防治中的应用
Author: Yahui XI ¹
Author Information

1. 150001,哈尔滨医科大学附属第一医院眼科
Keywords: Lens epithelial cells; Posterior capsule opacification; RNA interference; Transforming growth factor β2
From: Chinese Journal of Experimental Ophthalmology 2017;35(12):1126-1129
CountryChina
Language:Chinese
Abstract: Posterior capsule opacification (PCO) is a common complication after cataract phacoemulsification with intraocular lens (IOL) implantation.The mechanism of lens epithelial cells (LECs) fibrosis,PCO and capsular wrinkle is mainly related with residual LECs migration,proliferation and epithelialmesenchymal transition (EMT) after cataract surgery.Transforming growth factor β2 (TGF-β2) has been proposed as the most important factor driving the EMT and pathologic fibrosis of LECs,TGF-β2 induces LECs EMT by the Smad signaling pathway.Besides,PI3K/AKT/mTOR signaling pathway was studied to participate in TGF-β2 induced EMT.As one of the gene regulation methods,RNA interference (RNAi) technology shows an important application prospect in inhibiting LECs fibrosis and proliferation by interfering signaling pathway.This review highlights RNAi effects on LECs biological behavior by interfering PI3K/AKT/mTOR and TGF-β2/Smad signaling pathways.