Research progress of long noncoding RNAs in ocular proliferative diseases
10.3760/cma.j.issn.2095-0160.2017.12.017
- VernacularTitle:长链非编码RNA与眼部增生性疾病
- Author:
Xiaobo HUANG
1
Author Information
1. 226001,南通大学附属南通市第一人民医院眼科
- Keywords:
Proliferative vitreous retinopathy;
Diabetic retinopathy;
Choroidal neovascularization;
Corneal neovascularization;
Long noncoding RNA
- From:
Chinese Journal of Experimental Ophthalmology
2017;35(12):1135-1138
- CountryChina
- Language:Chinese
-
Abstract:
Ocular proliferative diseases,such as proliferative vitreous retinopathy (PVR),diabetic retinopathy (DR),choroidal neovascularization,corneal neovascularization and so on,often do harm to the structure and function of the eyes,and responses to treatments of late stage of these diseases are poor.Long noncoding RNAs (lncRNAs) with a length greater than 200 nucleotides can not directly encode a protein but can regulate the expression of protein coding genes through various pathways,and are widely involved in the regulation of body growth,as well as in cell apoptosis,proliferation and differentiation.More and more evidence suggests that lncRNAs are involved in the occurrence and development of a variety of ocular diseases.In the present paper,the concept,classification and mechanism of lncRNAs,and recent advances in the role of lncRNAs in PVR,DR,choroidal neovascularization and corneal neovascularization were reviewed.
