The distribution of vitamin D receptor gene polymorphisms in patients with chronic obstructive pulmonary disease in Changsha

VernacularTitle:长沙地区慢性阻塞性肺疾病患者维生素D受体基因多态性分布
Author: Ping ZHANG ¹ ; Yingqun ZHU ; Zhe LI ; Du FAN ; Longpei HE
Author Information

1. 长沙市第三医院呼吸内科
Keywords: Pulmonary disease,chronic obstructive/GE; Receptors,calcitriol/GE; Polymorphism,single nucleotide
From: Journal of Chinese Physician 2017;19(11):1615-1617
CountryChina
Language:Chinese
Abstract: Objective To investigate the genetic predisposing factor of chronic obstructive pulmonary disease (COPD) by studying the distribution of vitamin D receptor (VDR) gene polymorphisms in patients with COPD in Changsha.Methods Totally 120 COPD patients and 120 volunteers were enrolled in the study.Polymorphisms of VDR genes including Apa I and Bsm I were detected with polymerase chain reaction-restriction fragments length polymorphism (RFLP).Results There existed statistical difference in polymorphism of Apa I gene and frequency of distribution on its allele between two groups (P ＜ 0.05),while there is no significant difference on Bsm I gene between the two groups (P ＞ 0.05).Conclusions COPD is associated with the polymorphism of VDR-Apa I.There may be no relationship on VDR-Bsm I between two groups.