Action and mechanism of oxidative stress mediated by TXNIP in diseases
10.3969/j.issn.1001-1978.2018.01.005
- VernacularTitle:TXNIP介导的氧化应激在疾病中的作用机制
- Author:
lin Yu MO
1
;
jun Ya YANG
;
Liao CUI
Author Information
1. 广东医科大学药理学教研室
- Keywords:
thioredoxin-interacting protein ( TXNIP);
oxidative stress;
mitochondrial stress;
endoplasmic reticulum stress;
cel-lular inflammation;
cellular apoptosis
- From:
Chinese Pharmacological Bulletin
2018;34(1):16-19
- CountryChina
- Language:Chinese
-
Abstract:
Thioredoxin-interacting protein ( TXNIP) suppresses the antioxidative function of thioredoxin ( Trx ) by combining with thioredoxin ( Trx).Therefore, it promotes the generation and accumulation of reactive oxygen species ( ROS ) , inducing endoplasmic reticulum stress and mitochondrial stress , which leads to cellular inflammation or cellular apoptosis ultimately . TXNIP-mediated oxidative stress plays a crucial role in control-ling the generation and development of some diseases , such as diabetes and its complications ( diabetic nephropathy diabetic retinopathy etc .) , atherosclerosis ischemia/reperfusion injury , cancers ( hepatocellular carcinoma , carcinoma of urinary blad-der, mammary cancer , leukemia ) etc.Here, we try to review the action and mechanism of oxidative stress mediated by TXNIP in the diseases and the progress in research .
