Expression of Aurora-A in cervical cancer and precancerous lesions,and its correlation with HPV infec-tion
10.11904/j.issn.1002-3070.2017.06.003
- VernacularTitle:Aurora-A在宫颈癌及癌前病变中的表达以及与HPV感染的相关性研究
- Author:
Lei LEI
1
;
Qinghua YE
;
Guozeng WANG
;
Xianli HUANG
;
Qianyu WU
Author Information
1. 同济大学附属东方医院妇产科 上海 200123
- Keywords:
Aurora-A;
Centrosome;
Human papillomavirus;
Cervical intraepithelial neoplasia;
Cervical cancer
- From:
Practical Oncology Journal
2017;31(6):494-499
- CountryChina
- Language:Chinese
-
Abstract:
Objective The objectives of this study were to investigate the expression of Aurora-A pro-tein in cervical cancer and precancerous lesions,and its relationship with human papilloma virus( HPV) infection, and to analyze the role of Aurora-A in the pathogenesis of cervical cancer. Methods One hundred cases of cer-vical biopsy or surgical resection specimens were collected from high-risk HPV( HR-HPV) test. There were 20 cases of normal cervical tissues,20 cases of CIN grade 1 ( CIN1 ) ,20 cases of CIN grade 2 ( CIN2 ) ,20 cases of CIN grade 3(CIN3),and 20 cases of cervical squamous cell carcinoma. The expression of Aurora-A protein was detected by immunohistochemistry and the correlation between Aurora-A expression and HR -HPV infection was analyzed. Results Aurora-A was highly expressed in cervical intraepithelial neoplasia and cervical cancer (P<0. 05),and its positive expression rate increased with the degree of cervical lesions. There was a positive correlation between Aurora-A expression and cervical cancer(r=0. 475,P<0. 001). There was a positive cor-relation between Aurora-A expression and HR-HPV infection in CIN2 and CIN3(V=0. 591,P<0. 05). Con-clusion Aurora-A may be associated with the development of cervical cancer. Aurora-A can be used as an important biomarker for the early diagnosis of cervical intraepithelial neoplasia or cervical cancer. It is also a po-tential therapeutic target for cervical cancer.
