Research progress on cadherins and integrins in ovarian epithelial cancer
10.11904/j.issn.1002-3070.2017.06.013
- VernacularTitle:钙黏素和整合素在卵巢上皮性癌中的研究进展
- Author:
Xin LIU
1
;
Yingjuan XU
;
Chang YANG
Author Information
1. 哈尔滨医大学附属肿瘤医院妇科 哈尔滨 150001
- Keywords:
Epithelial ovarian cancer;
Cadherins;
Integrin;
Signal transduction
- From:
Practical Oncology Journal
2017;31(6):548-553
- CountryChina
- Language:Chinese
-
Abstract:
Epithelial ovarian cancer( EOC) is the most deadly malignant tumor in gynecological cancer. In the past 30 years,although the levels of diagnosis and treatment have made progress,the incidence of EOC and mortality are constant. Over the past few decades,a comprehensive study for molecular mechanisms of EOC pro-gression has been conducted in order to develop new and more effective treatments. Advanced peritoneal metasta-ses occur in the attached small clusters of cancer cells,which shed from the initial site and carried it through the ascites to the abdominal peritoneum or omentum. This behavior suggests that cell-cell or cell-matrix adhesion mechanisms regulate the growth and dissemination of EOC. Complex downstream signaling may be affected by functional crosstalk between adhesion molecules and,co-expressed and activated signaling proteins,which affect the proliferation/survival and migration/invasion of EOC cells. The aim of this review is to define effects of cell and cellular mechanisms,which are adhered by the cadherin and the cell-extracellular matrix,and cascaded by integrin-mediated membrane receptor and cytoplasmic protein -mediated cascade amplification, which is ex-pressed in proliferation,migration and invasion of epithelial ovarian cancer cells.
