The potential molecular effects of bursal septpeptide II on immune induction and antitumor activity.
10.4142/jvs.2015.16.3.325
- Author:
Guang Fang ZHOU
1
;
Qing Tao LIU
;
Bin ZHOU
;
Ya Feng QIU
;
Xiao Dong LIU
;
Zhi Yong MA
;
Xiu Li FENG
;
Rui Bing CAO
;
Pu Yan CHEN
Author Information
1. Division of Key Lab of Animal Disease Diagnosis and Immunology of China's Department of Agriculture, College of Veterinary Medicine, Nanjing Agriculture University, Nanjing 210095, China. xiulifeng@njau.edu.cn, crb@njau.edu.cn
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
bursal septpeptide II;
humoral immune system;
pathway analysis;
tumor suppressor p53
- MeSH:
Animals;
Antineoplastic Agents/*pharmacology;
Avian Proteins/*pharmacology;
Bursa of Fabricius/immunology;
Cell Proliferation/drug effects;
Chickens/*immunology;
Hybridomas/drug effects;
Immunologic Factors/*pharmacology;
Oligonucleotide Array Sequence Analysis/veterinary;
Signal Transduction/*drug effects;
*Transcriptome
- From:Journal of Veterinary Science
2015;16(3):325-331
- CountryRepublic of Korea
- Language:English
-
Abstract:
The bursa of Fabricius (BF) is the acknowledged central humoral immune organ in birds. Bursal septpeptide II (BSP-II) is an immunomodulatory bioactive peptide isolated from BF. To understand the effects of BSP-II on immune induction, gene expression profiles of hybridoma cells treated with BSP-II were evaluated. Pathway analysis showed that regulated genes were involved in cytokine-cytokine receptor interactions, T cell receptor signaling pathway, and pathway in cancer. It was observed that BSP-II reduced tumor cells proliferation and stimulated p53 expression. These results indicate potential mechanisms underlying the effects of the humoral immune system on immune induction, including antitumor activities. Our study has provided a novel insight into immunotherapeutic strategies for treating human tumors.
