Clinical study of caffeine citrate and aminophylline in treatment of primary apnea of prematurity
10.7501/j.issn.1674-6376.2017.11.019
- VernacularTitle:枸橼酸咖啡因与氨茶碱治疗早产儿原发性呼吸暂停的临床对照研究
- Author:
Yu WANG
1
;
sha Sha NI
;
hua Li HAN
Author Information
1. 宝鸡市中心医院儿科
- Keywords:
aminophylline;
caffeine citrate;
prematurity;
primary apnea
- From:
Drug Evaluation Research
2017;40(11):1622-1625
- CountryChina
- Language:Chinese
-
Abstract:
Objective Discuss the clinical efficacy of caffeine citrate and aminophylline in treatment of primary apnea of prematurity.Methods 80 cases of primary apnea of prematurity were selected.They were divided into two groups randomly.The control group (40 cases) received aminophylline treatment and the observation group (40 cases) received caffeine citrate therapy.The efficacy of caffeine citrate and aminophylline in treatment of primary apnea ofprematudty was evaluated by efficacy,primary apnea episodes and disappeared time,adverse reaction during treatment.Results The effective rate of observation group was 85％,the effective rate of control group was 75％.The observation group had higher efficiency (P ＜ 0.05).The frequency of apnea of observation group was less than that of the control group.The disappearance time of observation group was shorter than that of the control group (P ＜ 0.05).During the treatment,the tachycardia,feeding intolerance,bronchopulmonary dysplasia and other adverse reactions rate of observation group was lower than that of the control group (P ＜ 0.05).Conclusion Compared with aminophylline,caffeine citrate had a good therapeutic effect of primary apnea of prematurity.It can reduce apnea frequency,eliminate clinical symptoms with high safety.It was an ideal drug for treatment of primary apnea.
