Systematic review of aspirin for preventing venous thromboembolism after major orthopedic surgery
10.7501/j.issn.1674-6376.2017.11.025
- VernacularTitle:阿司匹林预防骨科大手术后静脉血栓栓塞症的系统评价
- Author:
Hua GUO
1
;
Qiang FU
;
qing Jun ZHANG
;
Pei WANG
;
li Yan REN
Author Information
1. 郑州大学第三附属医院药学部
- Keywords:
aspirin;
orthopedic surgery;
venous thromboembolism;
systematic review
- From:
Drug Evaluation Research
2017;40(11):1645-1651
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically review the efficacy and safety of aspirin for preventing venous thromboembolism (VTE) after major orthopedic surgery.Methods Retrieved from PubMed,Embase and Cochrane Library,randomized controlled trials (RCT) and cohort studies about aspirin used in major orthopedic surgery were collected.Meta-analysis was performed by using Rev Man 5.3 software after data extraction and quality evaluation.Results Totally seven RCTs and five cohort studies were included.Compared with control group,aspirin reduced the incidence of deep vein thrombosis (DVT) [RR=0.69,95％CI(0.54,0.89),P =0.004] and pulmonary embolism(PE) [RR =0.60,95％CI(0.43,0.84),P =0.003].Compared with low molecular weight heparin (LMWH),the incidence ofDVT,PE and hemoglobin drop were [RR =1.06,95％CI(0.96,1.17),P =0.22],[RR =1.04,95％CI(0.93,1.18),P =0.48] and [MD =-7.61,95％CI(-11.73,-3.49),P =0.000 3] respectively in aspirin group.Conclusions Compared with control,aspirin could reduce VTE incidence after major orthopedic surgery.There were no significant differences in VTE incidence between aspirin and LMWH,but hemoglobin drop were lower in aspirin group.For other complications,there were no significant differences between aspirin and control/LMWH.
