Serum adipokine concentrations in dogs with diabetes mellitus: a pilot study.
10.4142/jvs.2015.16.3.333
- Author:
Ah Young KIM
1
;
Hye Sun KIM
;
Ji Houn KANG
;
Mhan Pyo YANG
Author Information
1. Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Korea. jhkang@chungbuk.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
adiponectin;
canine;
interleukin;
leptin;
visfatin
- MeSH:
Adipokines/*blood;
Animals;
Case-Control Studies;
Diabetes Mellitus, Type 2/*blood/etiology;
Dogs;
Female;
Male;
Pilot Projects;
Prospective Studies
- From:Journal of Veterinary Science
2015;16(3):333-340
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study was conducted to determine whether serum adipokine concentrations differed between healthy dogs and dogs with diabetes mellitus (DM). To accomplish this, 19 dogs with newly diagnosed DM were compared to 20 otherwise healthy dogs. The serum concentrations of visfatin, leptin, IL-1beta, IL-6, IL-18, and TNF-alpha were significantly higher in diabetic dogs than in healthy dogs, whereas the serum adiponectin concentrations were lower in diabetic dogs. However, there were no significant differences in the IL-10 and resistin levels between groups. The serum leptin concentrations in diabetic dogs with and without concurrent disorders differed significantly. Treatment with insulin induced a significant decrease in IL-6 in diabetic dogs without concurrent disorders. These results show that the clinical diabetic state of dogs could modulate the circulating visfatin and adiponectin concentrations directly, while upregulation of leptin was probably a result of concurrent disorders rather than an effect of persistent hyperglycemia as a result of DM.
