Prognostic factors of transcatheter arterial chemoembolization for primary hepatocellular carcinoma
10.13929/j.1672-8475.201704027
- VernacularTitle:肝动脉化疗栓塞术治疗原发性肝细胞癌预后影响因素分析
- Author:
Yubo LIAO
1
;
Yan ZHAO
;
Hongtao HU
;
Chenyang GUO
;
Junli MA
;
Li JIANG
;
Hailiang LI
Author Information
1. 郑州大学附属肿瘤医院河南省肿瘤医院放射介入科
- Keywords:
Carcinoma,hepatocellular;
Chemoembolization,therapeutic;
Prognosis
- From:
Chinese Journal of Interventional Imaging and Therapy
2017;14(12):729-733
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prognostic factors of transcatheter arterial chemoembolization (TACE) in the treatment of primary hepatocellular carcinoma (HCC).Methods A retrospective analysis was performed on 326 HCC patients treated with TACE.Kaplan-Meier method was used to calculate the 1-year,2-year and 3-year cumulative survival rates.Log-rank test and Cox proportional hazards model were used to analyze univariate and multivariate prognostic factors,respectively.Results The 1-year,2-year and 3-year cumulative survival rate of HCC patient was 73.90％,40.20％and 22.20％,respectively.The median survival time was 21 months.Univariate analysis showed that the alpha-fetoprotein (AFP),gamma-glutamyl transpeptidase (GGT),tumor size,tumor number,Child-Pugh grade,Barcelona clinic liver cancer (BCLC) stage,portal vein thrombosis,arteriovenous fistula and distant metastasis were factors affecting the prognosis of HCC patient (all P＜0.05).Multivariate COX regression analysis showed that AFP,GGT,tumor size,tumor number,BCLC stage,arteriovenous fistula were the independent prognostic factors of HCC patients (all P＜0.05).Conclusion AFP,GGT,tumor size,tumor number,BCLC stage and arteriovenous fistula are independent prognostic factors of HCC patients treated with TACE.
