Advances in NMDA receptors-related antidepressants
10.3969/j.issn.1001-1978.2018.01.001
- VernacularTitle:NMDA受体相关抗抑郁药物的研究进展
- Author:
fen Guang ZHANG
1
;
jun Jian YANG
Author Information
1. 东南大学附属中大医院麻醉科
- Keywords:
N-methyl-D-aspartate receptor;
ketamine;
metabo-lites;
isomeride;
isoforms;
antidepressant
- From:
Chinese Pharmacological Bulletin
2018;34(1):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies have demonstrated that ketamine , an N-methyl-D-aspartate ( NMDA ) receptor antagonist , can pro-duce rapid and effective antidepressant actions , especially for patients with treatment-resistant depression , bipolar disorder and suicide idea.However, the clinical application of ketamine is limited by its psychotomimetic adverse reactions and potential a-buse.Therefore, development of novel ketamine-like antidepres-sant agents with fewer side effects is actively investigated currently.The latest researches indicate that the metabolites of ket-amine, the S-ketamine/R-ketamine and the modulators of NM-DA receptor subunits can exert safe and effective antidepressant actions.In this article, the research advance in NMDA recep-tors-related antidepressants mentioned above will be reviewed .
