Role of acid-sensing ion channel 1a in pathogenesis of autoimmune diseases
10.3969/j.issn.1001-1978.2018.01.004
- VernacularTitle:酸敏感离子通道1a在自身免疫性疾病发病机制中的研究进展
- Author:
Yong CHEN
1
;
fang Jin GE
;
hu Fei CHEN
Author Information
1. 安徽医科大学药学院
- Keywords:
acid-sensing ion channel 1a;
autoimmune disea-ses;
acidosis;
inflammation;
mechanism;
target
- From:
Chinese Pharmacological Bulletin
2018;34(1):12-15
- CountryChina
- Language:Chinese
-
Abstract:
Acid-sensing ion channels ( ASICs) are proton-gated channels expressed widely in the central nervous systems and pe-ripheral tissues, among which ASIC1a is a core part and plays an important role in many physiological and pathological proces-ses.As a key receptor for extracellular protons , ASIC1a is in-volved in a variety of pathophysiological processes involving tis-sue acidosis, such as pain, inflammation, seizures and multiple sclerosis.Autoimmune disease is a chronic inflammatory dis-ease , and the excessive activation of T , B cells leads to multiple tissue and organ damage when the body responds to autoantigen immune response . In recent years , studies have found that ASIC1a plays an important role in the development of various au-toimmune diseases.In this paper, the biological characteristics of ASIC1a are briefly reviewed , and the research progress of ASIC1a in the development and progression of autoimmune dis-eases is discussed .
