Investigation and Analysis of Off-label Use of Omeprazole in Outpatient Department of a Hospital
10.6039/j.issn.1001-0408.2017.35.06
- VernacularTitle:某院门诊奥美拉唑超说明书用药情况调查分析
- Author:
Wei JIANG
1
;
Xiaoling WU
;
Minhua ZHOU
;
Yidan XIE
;
Yan WANG
;
Guanghong HUANG
Author Information
1. 广州中医药大学附属广东中西医结合医院
- Keywords:
Outpatient department;
Omeprazole;
Off-label drug use;
Analysis
- From:
China Pharmacy
2017;28(35):4918-4921
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the omeprazole off-label use and provide reference for rational drug use in clinic. METHODS:In retrospective survey,1838 omeprazole prescriptions were selected from outpatient department during Jun. 2014 to May 2017 by random number table. According to the latest drug instruction,whether the off-label use or not was determined. Off-label use was determined by reviewing domestic and foreign guidelines,literatures and Micromedex database. RESULTS:Among 1838 pre-scriptions,there were 1750 prescriptions of off-label drug use (95.21％),involving 13 items and 3 types of off-label drug use. Main type of off-label drug use was over-indication medication,involving 1747 prescriptions (96.47％). There was no statistical significance in the incidence of off-label drug use between digestive department and non-digestive department or among physicians at different levels(P>0.05). Among 13 items of off-label drug use,7 items were supported by evidence-based medicine evidence of domestic and foreign guideline,expert consensus/suggestion or literature reports,etc.;among which 1 item of off-label drug use were included in Micromedex grading system and other 6 items had no evidence-based medicine evidence. CONCLUSIONS:The phenomenon of omeprazole off-label use is widespread in outpatient department of the hospital,and some off-label drug use are sup-ported by evidences. There are differences in the quality of those evidences. It is suggested to standardize the off-label drug use to avoid legal risks and guarantee the safety of drug use for patients.
