Effects of Qigong Pills Formula on Uterine Artery Blood Flow and Endometrial Receptivity of Patients with Polycystic Ovary Syndrome with Infertility
10.6039/j.issn.1001-0408.2017.35.19
- VernacularTitle:启宫丸方对多囊卵巢综合征伴不孕症患者子宫动脉血流和内膜容受性的影响
- Author:
Lianlian ZHANG
1
;
Zaigang HAN
;
Rui YANG
Author Information
1. 北华大学附属医院药学部
- Keywords:
Qigong pills formula;
Polycystic ovary syndrome;
Infertility;
Uterine artery;
Endometrial receptivity
- From:
China Pharmacy
2017;28(35):4967-4970
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of Qigong pills formula on uterine artery blood flow and endometrial recep-tivity of patients with polycystic ovary syndrome(PCOS)with infertility. METHODS:A total of 86 PCOS patients with infertility in our hospital during Jan.-Dec. 2016 were divided into control group and observation group according to random number table, with 43 cases in each group. Control group was given western medicine pituitary down-regulation therapy. Observation group was additionally given adjuvant therapy of Qigong pills formula,a dose per day,decocted with water to 400 mL,morning and night un-til artificial fertilization stopped,on the basis of control group. The uterus ultrasonic indexes and endometrial receptivity were com-pared between 2 groups before treatment and 3 months after treatment. The occurrence of ovulation,pregnancy and ADR was re-corded. RESULTS:Before treatment,there was no statistical significance in uterus ultrasonic indexes and endometrial receptivity in-dexes between 2 groups (P>0.05). Three months after treatment,endometrial thickness of 2 groups were increased significantly, while endometrial spiral arterial pulsatility indexes and resistance indexes were decreased significantly;the levels ofαvβ3 and GLUT4 were increased significantly;observation group was significantly better than control group,with statistical significance (P<0.05). The ovulation rate of observation group was 83.72％,which was significantly higher than 62.79％ of control group,with statistical significance(P<0.05). There was no statistical significance in pregnancy rate(27.91％ vs. 18.60％)between 2 groups(P>0.05). No obvious ADR was found in 2 groups. CONCLUSIONS:The adjuvant therapy of Qigong pills formula help to regulate the pa-rameters of uterine artery blood flow in PCOS patients with infertility,and strengthen endometrial receptivity so as to increase ovu-lation rate.
