Effects of Levetiracetam on Sex Hormone and Thyroid Hormone of Epileptic Children
10.6039/j.issn.1001-0408.2017.35.20
- VernacularTitle:左乙拉西坦对癫痫患儿性激素和甲状腺激素的影响
- Author:
Shengquan WANG
1
;
Hui ZHOU
Author Information
1. 无锡市儿童医院儿科
- Keywords:
Epilepsy;
Levetiracetam;
Sex hormones;
Thyroid hormone;
Children
- From:
China Pharmacy
2017;28(35):4970-4974
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of levetiracetam on sex hormone and thyroid hormone of epileptic children and to evaluate its safety. METHODS:A total of 22 newly diagnosed epileptic children were selected from the Affiliated Hospital of Nantong University(hereinafter refferred as our hospital)during Jul. 2013-Feb. 2015 as observation group. During same peri-od,17 children underwent physical examination in our hospital were selected as control group. Observation group was given Le-vetiracetam tablets with initial dose of 10 mg/kg,increasing by 10 mg/(kg·d) every week or every two weeks [target dose of 30-40 mg/(kg·d)] for 12 months. The levels of sex hormone(follicle stimulating hormone,luteinizing hormone,prolactin,proges-terone,testosterone and estradiol)and thyroid hormone(TT3,TT4,FT3,FT4,TSH)were observed before medication in control group and before and 3,6,12 months after medication in observation group. The occurrence of ADR was recorded in observation group. RESULTS:Before medication,there was no statistical significance in the levels of sex hormone or thyroid hormone be-tween 2 groups(P>0.05). Three,six,twelve months after medication,there was no statistical significance in the levels of sex hormone in observation group compared to before medication(P>0.05). Three,six months after medication,there was no statis-tical significance in the levels of thyroid hormone in observation group compared to before medication (P>0.05). Twelve months after medication,there was no statistical significance in the levels of TT3,TT4,FT4 or TSH compared to before medi-cation(P>0.05);the level of FT3 was increased significantly,with statistical significance(P<0.05). Two cases of observation group suffered from ADR (9.1％). Without special treatment,the symptoms all disappeared 1-2 weeks later. CONCLUSIONS:Levetiracetam can be used for pediatric epilepsy and has no significant effects on the level of sex hormone,but increases the lev-el of FT3.
