Epidemiological and clinical characteristics of 16 cases of gnathostomiasis
10.3969/j.issn.1002-2694.2017.11.018
- VernacularTitle:颚口线虫病16例流行病学及临床特征分析
- Author:
An MA
1
;
Yue WANG
;
long Xiao LIU
;
xian Xiao GAN
Author Information
1. 浙江省医学科学院寄生虫病研究所
- Keywords:
gnathostomiasis;
epidemiology;
clinical manifestation;
diagnosis;
treatment
- From:
Chinese Journal of Zoonoses
2017;33(11):1048-1051
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the epidemiological and clinical characteristics of emerging infectious gnathostomiasis in China,a retrospective analysis was performed on 16 cases of gnathostomiasis found during 2009-2011.Patients consisted of 11 women and 5 men.The median age was 48 years (ranging from 27 to 68years).Eleven out of 16 patients (68.8%) had history of ingesting raw or undercooked freshwater fish.The main manifestation of patients was cutaneous form.Clinical symptoms included migratory swelling,creeping eruption and skin rash.Among them,43.8% (7/16) of patients presented eosinophilia.The results of serological tests showed all patients were Gnathostoma-specific IgG positive by dot immunogold fitration assay (DIGFA) and 5 cases (31.2 %) were positive by immunoblot for detection of specific 24-kDa protein band reaction.The median time from onset of symptoms to diagnosis was 12 months with a range of 2 weeks to 3 years.A total of 11 patients were treated with albendazole and/or ivermectin.Ten patients did not relapse post treatment.During 2009-2011,the number of patients with gnathostomiasis significantly increased due to consumption of raw or under-cooked loaches and swamp eels.Serological test was a necessary tool to support clinical diagnosis while gnathostomiasis commonly presented complex symptoms.Ivermectin and albendazole were effective to treat gnathostomiasis.