Add-On Therapy of Quetiapine for Bipolar Disorder: A 6 Month, Prospective Trial.
- Author:
Chi Un PAE
1
;
Tae Suk KIM
;
Young Ji LEE
;
Jung Jin KIM
;
Soo Jung LEE
;
Chang Uk LEE
;
Chul LEE
;
In Ho PAIK
Author Information
1. Department of Psychiatry, Kangnam St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Seoul, Korea. jihan@cmc.cuk.ac.kr
- Publication Type:Original Article
- Keywords:
Quetiapine;
Adjunctive;
Long-term treatment;
Bipolar disorder
- MeSH:
Bipolar Disorder*;
Depression;
Humans;
Prospective Studies*;
Psychomotor Agitation;
Quetiapine Fumarate
- From:Korean Journal of Psychopharmacology
2005;16(4):279-284
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: This study was conducted to evaluate the overall effectiveness and tolerability of adjunctive quetiapine in the long-term treatment of bipolar disorder as a continuation therapy. METHODS: Twenty-three bipolar I patients participated and required to have quetiapine add-on treatment in combination with existing or new mood stabilizers. Clinical assessment was carried out using Young Mania Rating Scale (YMRS), Clinical Global Impression (CGI), Hamilton Depression Rating Scale-17 item, Simpson-Angus Rating Scale and Barnes Akathisia Rating Scale at baseline, 1, 4, 12 and 24 weeks. RESULTS: The YMRS and CGI decreased significantly from baseline to endpoint by 89.7% and 78.3%, respectively (p<0.0001 ; p<0.0001). Twenty-two patients exhibited at least 50% improvement on YMRS score by the end of the study. CONCLUSION: This study suggests that quetiapine may hold a promise as an adjunct in the long-term treatment of bipolar disorder.
