The clinical effects of Dexmedetomidine on analgesia and postoperative cognitive function in elderly patients with lumbar spine surgery
10.3760/cma.j.issn.0254-9026.2017.12.011
- VernacularTitle:右美托咪定对老年患者腰椎术全麻镇痛的疗效及术后认知功能的影响
- Author:
Jing ZHOU
1
;
Caifang LI
;
Changdong FENG
;
Qinyun WANG
;
Fuhai JI
Author Information
1. 215006,苏州大学附属第一医院麻醉科
- Keywords:
Dexmedetomidine;
Lumbar surgery;
General anesthesia analgesia;
Postoperative cognitive dysfunction
- From:
Chinese Journal of Geriatrics
2017;36(12):1323-1325
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effects of Dexmedetomidine on analgesia and postoperative cognitive function in elderly patients with lumbar spine surgery.Methods The patients were randomly divided into the control group (n=88) and the study group (n=100).The patients in the study group were treated with Dexmedetomidine at a loading dose of 1.0 μg/kg for 15 min,and 0.3 μg · kg-1 · h 1 was continuously pumped.The anesthetic mode and drugs in the control group were similar to those in study group,except that Dexmedetomidine in the study group was replaced with physiological saline in the control group.Intraoperatively used dose of analgesic drugs,and pain and cognitive function changes were compared between the two groups.Results The intraoperatively used doses of Remifentanil,Fentanyl and propofol were significantly lower in the study group than in the control group (P＜0.05).The VAS scores were markedly lower in the study group than in the control group (2.6±0.5 vs.4.5± 1.2,t=4.9398,P=0.0000).The MMSE scores were higher in the study group than in the control group (28.0 ± 1.3 vs.26.0 ± 2.5,t =-6.6484,P=0.0000).Conclusions Intraoperative use of Dexmedetomidine for treatment of the elderly patients with lumbar surgery will not only reduce the perioperatively used dose of analgesic and sedative drug,but also reduce postoperative pain and improve postoperative cognitive function.
