Azathioprine-induced myelosuppression in a pemphigus patient with a heterozygous mutation in the NUDT15 gene
10.3760/cma.j.issn.0412-4030.2017.12.012
- VernacularTitle:硫唑嘌呤致NUDT15杂合突变天疱疮患者骨髓抑制一例
- Author:
Lian WANG
1
;
Yanhong ZHOU
;
Xingli ZHOU
;
Xiaoyan LYU
;
Xin ZENG
;
Wei LI
Author Information
1. 四川大学华西医院皮肤科
- Keywords:
Azathioprine;
Pemphigus;
Heterozygote;
Bone marrow;
NUDT15
- From:
Chinese Journal of Dermatology
2017;50(12):912-914
- CountryChina
- Language:Chinese
-
Abstract:
A 49-year-old male patient presented with repeated oral erosions for 1 year,as well as cutaneous erythema and blisters for 1 month.According to histopathological examination and detection of specific antibodies of pemphigus,the patient was diagnosed with pemphigus vulgaris.After the treatment with oral prednisone and azathioprine for 1 month,the white blood cell count and segmented neutrophilic granulocyte count both decreased.After withdrawal of azathioprine,the patient was subcutaneously injected with 150 μg recombinant human granulocyte colony-stimulating factor for 1 session.Then,the white blood cell count became normal.Genotyping test revealed that the patient carried a heterozygous mutation in the NUDT15 gene (JZ274),and was homozygous for wild-type TPMT*2,TPMT*3C and ITPA genes.The patient was diagnosed with azathioprine-induced myelosuppression.
