Expression of HIF-2α and VEGF in colorectal cancer and its relationship with prognosis
10.3969/j.issn.1671-8348.2017.34.015
- VernacularTitle:HIF-2α及VEGF在结直肠癌组织中的表达及与患者预后的关系
- Author:
Chengcheng HUANG
1
;
Chengjia TANG
;
Tianwu YU
Author Information
1. 重庆医科大学附属永川医院老年病科 402160
- Keywords:
colorectal neoplasms;
hypoxia-inducible factor 2α;
vascular endothelial growth factor A
- From:
Chongqing Medicine
2017;46(34):4802-4804
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of HIF-2α and VEGF in colorectal cancer and to investigate the relationship between them and clinicopathologic parameter.Methods Immunohistochemistry staining was conducted to detect the expression of HIF-2α and VEGF protein in 67 samples of colorectal tumor tissues and 67 samples of normal adjacent tissue.Results The expression of HIF-2α and VEGF in colorectal cancer tissues was significantly higher than that in adjacent tissues.The expression of HIF-2α and VEGF increased with the clinical stage and lymph node metastasis.The expression of HIF-2α increased with the tumor volume.The expression of HIF-2α and VEGF was not related to the age,sex,tumor location and tumor differentiation of the patients.HIF-2α was positively correlated with VEGF expression.Kaplan-Meier survival analysis showed that HIF-2α expression was associated with survival,that is,the higher expression of HIF-2α the worse of prognosis was obtained.Conclusion HIF-2α is involved in the process of growth,invasion and metastasis of colorectal cancer.This process may be related to the regulation of VEGF expression.
