Relationship between inflammatory factors and carotid atherosclerosis in OSAHS patients with type 2 diabetes mellitus
10.3969/j.issn.1671-8348.2017.34.017
- VernacularTitle:OSAHS合并2型糖尿病患者炎症因子与颈动脉粥样硬化关系
- Author:
Chengcheng HUANG
1
;
Chengjia TANG
;
Xiaoli LONG
;
Zeyi LING
;
hongli GAO
Author Information
1. 重庆医科大学附属永川医院老年病科 402160
- Keywords:
diabetes mellitus,type 2;
sleep apnea syndromes;
tumor necrosis factor-alpha;
C-reactive protein
- From:
Chongqing Medicine
2017;46(34):4807-4809
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum inflammatory cytokines and atherosclerosis in type 2 diabetic patients with obstructive sleep apnea hypopnea syndrome (OSAHS).Methods One hundred and three patients with type 2 diabetes were divided into OSAHS group (OSAHS group) and type 2 diabetes mellitus group (non-OSAHS group) according to the results of polysomnography(PSG),and 35 healthy subjects were selected as control group.Serum levels of total cholesterol,triglyceride,fasting plasma glucose(FPG),glycosylated hemoglobin(HbA1c),tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein (hs-CRP) and carotid intima-media thickness (IMT) were measured,and their relationship with OSAHS were analyzed.Results The waist circumference,BMI,FPG,HbA1c,IMT,TNF-α and CRP in OSAHS group were significantly higher than those in non-OSAHS group (P＜0.05).Logistic regression analysis showed that,IMT was independently associated with TNF-α and hs-CRP.Conclusion Patients of T2DM with OSAHS have poor blood glucose control and higher incidence of atherosclerosis.High levels of TNF-α and hs-CRP may be involved in the formation of atherosclerosis and plaque occurrence and development.
