Progress in the role of specific signaling pathways in bone repair and regeneration

VernacularTitle:特异性信号通路在骨修复和再生中的作用研究进展
Author: Guoqiang XIAO ¹ ; Jieyu HU ; Qian WANG ; Qijia LI ; Zhiqiang WANG
Author Information

1. 华北理工大学附属医院骨科
Keywords: Bone Regeneration; Bone Defect; Mesenchymal Stem Cells; Signaling Pathway
From: Clinical Medicine of China 2017;33(12):1138-1142
CountryChina
Language:Chinese
Abstract: Bone regeneration strategy to repair bone defects shows great potential.Although the skeleton has a strong self-healing and repair capabilities, for huge bone defect caused by trauma, congenital malformations,infection and surgery,the skeleton is difficult to complete the self-repairing process.In order to promote bone regeneration,bone growth must be induced by biologically active implants,cell and intracellular molecular signaling pathways.Mesenchymal stem cells(MSC)play an important role in bone repair and remodeling.Understanding the role of MSC and signaling pathways in bone repair and regeneration is critical for the study and development of bone repair materials.