Research advances of histone deacetylases in inflammatory respiratory diseases

VernacularTitle:组蛋白去乙酰化酶在呼吸道相关疾病中的作用及展望
Author: shi Dai CHEN ^{1
,

2} ; 518020深圳深圳市人民医院耳鼻咽喉头颈外科、暨南大学附属第二临床医学院 ; yang Zhao KE ; Lei CHEN
Author Information

1. 100853北京解放军总医院耳鼻咽喉头颈外科
2. 518020深圳深圳市人民医院耳鼻咽喉头颈外科、暨南大学附属第二临床医学院
Keywords: histone deacetylases; chronic nasosinusitis; allergic rhinitis; chronic obstructive pulmonary disease; athsma
From: Medical Journal of Chinese People's Liberation Army 2017;42(11):962-967
CountryChina
Language:Chinese
Abstract: Histone deacetylases (HDAC) are pivotal enzymes in many physiological processes widely expressed in almost all tissues including chromatin remodeling,regulation of protein transcription,cell cycle,aging,oxidative stress,inflammation and expression of immune genes.Recent studies indicated that the equilibrium state of histone acetylation and deacetylation is closely related to respiratory tract inflammation,and the unbalanced expression of HDAC could induce the expression of genes related to the inflammatory cytokines and oxidative stress.Now the structure and classification of HDAC and the updated results on HDAC in the inflammatory respiratory diseases are herewith reviewed in present paper.