Advances of phosphoinositide-3 kinase inhibitors in combination with other drugs to overcome drug resistance
10.11665/j.issn.1000-5048.20170503
- VernacularTitle:PI3K抑制剂与其他药物联用克服耐药性的研究进展
- Author:
Chengshu JIA
1
;
Junwei WANG
;
Hui LI
;
Qihua ZHU
;
Yiran GE
;
Yungen XU
Author Information
1. 中国药科大学药物化学系
- Keywords:
phosphatidylinositol-3-kinase;
PI3K inhibitors;
antitumor;
drug combination;
resistance
- From:
Journal of China Pharmaceutical University
2017;48(5):523-528
- CountryChina
- Language:Chinese
-
Abstract:
Phosphoinositide 3-kindase,an important signal transduction molecule in cells,plays a key role in the process of cell survival,proliferation and differentiation.Significant progress has been made in the treatment of cancer with PI3K inhibitors,yet the drug resistance of PI3K inhibitors affects their long-term efficacy in clinical treatment.In order to overcome the drug resistance,a variety of rational combined therapies have been developed.In this paper,the research progress of phosphoinositide-3 kinase inhibitors in combination with other drugs to overcome the drug resistance were reviewed.
