Study on serum S100A12 level in patients with obstructive sleep apnea hypopnea syndrome
10.3969/j.issn.1671-8348.2017.34.008
- VernacularTitle:阻塞性睡眠呼吸暂停低通气综合征患者血清S100A12水平的研究
- Author:
Peng ZHANG
1
;
Xiuhui CHENG
;
Hua ZHANG
;
Songyun OUYANG
;
Wenlong LI
;
Linqing GUO
;
Chao XU
;
Yuna ZU
;
Yongxin WU
Author Information
1. 郑州大学附属郑州中心医院呼吸科 450000
- Keywords:
sleep apnea,obstructive;
S100A12;
relationship
- From:
Chongqing Medicine
2017;46(34):4780-4782
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation and significance of S100A12 with obstructive sleep apnea hypopnea syndrome (OSAHS).Methods Fifty-three patients with OSAHS were chosen as OSAHS group and 46 healthy volunteers were chosen as control group.The levels of S100A12 and hs-CRP in the two groups were compared,and its relationship with those of epworth (ESS),apnea hypopnea index (AHI),and minimum blood oxygen saturation (L-SpO2) were analysised.Results The scores of ESS,BMI,A HI,L-SpO2,hs-CRP and S100A12 in two groups were statistically significant (P＜0.05).The severity of hs-CRP in severe OSAHS group was significantly higher than that of mild OSAHS group (P＜0.05).There was no significant difference in hs-CRP between moderate OSAHS group and mild OSAHS group and severe group (P＞0.05).The level of S100A12 in severe OSAHS group was significantly higher than that of moderate OSAHS group and OSAHS mild group(P＜0.05).The level of S100A12 in moderate moderate group was significantly higher than that of mild group(P＜0.01).hs-CRP was negatively correlated with ESS and AHI (r=0.822,0.787,P＜0.01),was positively correlated with L-SpO2 (r=-0.740,P＜0.01),S100A12 was positively correlated with ESS and AHI (r =0.707,P ＜ 0.01),and negatively correlated with ESS and AHI (r =0.707,0.807,P＜0.01),and negatively correlated with with L-SpO2 (r=-0.670,P＜0.01).Conclusion S100A12 is associated with OSAHS.The higher the severity of OSAHS,the higher the S100A12 value,which can be used as a new predictor of cardiovascular disease risk in OSAHS patients.
