Alkaloid constituents from Corydalis decumbens

VernacularTitle:夏天无中生物碱类化学成分的研究
Author: Qilong HUANG ¹ ; Wanjin ZHANG ; Yan LI ; Juan CHEN ; Baoping ZHOU ; Xiaohan ZOU ; Chunlei ZHANG ; Zhengyu CAO
Author Information

1. 中国药科大学江苏省中药评价与转化重点实验室
Keywords: Corydalis decumben; tubers; chemical constituents; alkaloid; isolation and identification
From: Journal of China Pharmaceutical University 2017;48(5):563-567
CountryChina
Language:Chinese
Abstract: To study alkaloid constituents in Corydalis decumbens,thirteen compounds were isolated from 95％ ethanol extracts of Corydalis decumbens (Thunb) Pers.by silica gel,RP-C1s,Sephadex LH-20 column chromatographer,recry stallization,thin-layer chromatography and HPLC.Their structures were elucidated on the basis of spectral data combined with physiochemical properties as tetrahydropalmatine (1),oxyhydrastinine (2),doryanine (3),palmatine (4),bicuculline (5),canadine (6),tetrahydrocoptisine(7),corydaldine (8),epicorynoxidine (9),N-methylcorydaldine (10),(+)-corlumine (11),N-methyl-6,7-dimethoxyisoquinolone (12) and oxysanguinarine (13).Compounds 2,3,6,7,and 9-13 were isolated from this plant for the first time.In addition,compounds 2,3,and 9-13 were obtained firstly from this genus.Pharmacological experiments showed that tetrahydropalmatine (1) might have analgesic or sedative effects,and the bicuculline (5) could probably induce epilepsy.