Study on extractables in disposable syringe materials
10.11665/j.issn.1000-5048.20170513
- VernacularTitle:一次性输液器组成材料的可提取物研究
- Author:
Mengyi CHEN
1
;
Hui YIN
;
Xiaohui LIU
;
Bin DI
Author Information
1. 中国药科大学药物分析系
- Keywords:
disposable syringe;
extracting test;
GC-MS;
volatile compounds
- From:
Journal of China Pharmaceutical University
2017;48(5):583-589
- CountryChina
- Language:Chinese
-
Abstract:
Extraction experiment of volatile compounds in disposable syringes from five manufacturers was undertaken by GC-MS with high-space injection and semi-volatile compounds were tested by GC-MS.MS detection ranged from 30 to 650 with electron ionization (EI) source.Vanillin was used as internal standard to monitor the sample pretreatment process.Liquid-liquid extraction (LLE) and solid-phase extraction (SPE) were compared to acquire a simple processing method with more extractables in syringe materials.HCl,NaOH,Tween 80 and ethanol-aqueous solution were used as extraction solvents.The method was successfully developed to determine the unknown volatile extractables and the results were used to investigate the safety of disposable syringes comprehensively.
