The relationship between serum Dickkopf-1 ,HE4 and PARP-1 levels and clinical staging of gastric cancer and lymph node metastasis and its clinical prognosis
10.3969/j.issn.1673-4130.2017.23.002
- VernacularTitle:胃癌患者血清中DKK-1、HE4、PARP-1水平与胃癌临床分期、淋巴结转移度及临床预后的关系
- Author:
Qihua XU
1
Author Information
1. 上海中医药大学附属第七人民医院
- Keywords:
gastric cancer;
lymph node metastasis;
clinical stage;
prognosis
- From:
International Journal of Laboratory Medicine
2017;38(23):3219-3221
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum Dickkopf-1 ,HE4 and PARP-1 levels and clinical staging of gastric cancer and lymph node metastasis and its clinical prognosis .Methods The serum levels of DKK-1 ,HE4 and PARP-1 in 50 patients with gastric cancer (gastric cancer group) and 50 healthy volunteers (control group) were measured by enzyme-linked im-munosorbent assay (ELISA) ,the relationship between serum Dickkopf-1 ,HE4 and PARP-1 levels and clinical staging of gastric cancer ,lymph node metastasis was analyzed .and the clinical prognosis was explored .Results Serum DKK-1 ,HE4 ,PARP-1 levels of gastric cancer group were (29 .6 ± 9 .6) ,(52 .6 ± 18 .6) ,(6 .1 ± 1 .8)μg/L respectively ,and the levels of control group were (5 .8 ± 1 .5) ,(17 .5 ± 2 .6) ,(3 .6 ± 1 .8)μg/L respectively .Serum DKK-1 ,HE4 and PARP-1 levels of gastric cancer group were signifi-cantly higher than those of control group ,DKK-1 ,HE4 ,PARP-1 levels were higher in gastric cancer patients with older age ,lower degree of differentiation ,in late clinical stage ,and with lymph node metastasis ;serum DKK-1 ,HE4 ,PARP-1 levels had no obvious relationship with gender and age but were positively related to TNM stage ,and lymph node metastasis ;DKK-1 (P=0 .04) ,HE4 (P=0 .03) and PARP-1 (P=0 .04) are independent risk factors of poor prognosis of patients with gastric cancer .Conclusion The levels of serum Dickkopf-1 ,HE and PARP-1 in patients with gastric cancer are closely related to the clinical prognosis of the pa-tients and are independent risk factors of poor prognosis .
