Study of correlation between serum miR-216a level and severity of acute pancreatitis
10.3969/j.issn.1673-4130.2017.23.005
- VernacularTitle:血清miR-216a水平与急性胰腺炎严重程度的相关性研究
- Author:
Jianbin WANG
1
;
Caiyue WU
;
Lisi WANG
;
Kaiming WU
Author Information
1. 广州医科大学附属乐从医院消化科
- Keywords:
serum;
acute pancreatitis;
miR-216a;
correlation
- From:
International Journal of Laboratory Medicine
2017;38(23):3228-3230
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between serum miRNA-216a level and severity of acute pancretitis (AP) .Meth-ods 17 cases of mild acute pancreatitis (MAP group) ,23 cases of severe acute pancreatitis (SAP group) and 30 cases of healthy subjective (control group) were selected in our hospital from June 2015 to June 2016 .Blood amylase activity and serum miRNA-216a were detected ,Ranson value ,APACHEⅡvalue and modified CT severity index (MCTSI) were used to evaluate the severity of AP ,analyze the correlation between miR-216a level and other indexes .Results The serum amylase activity of MAP group and SAP group in acute stage were higher than those in convalescence in these groups and the control group (P<0 .05) ,and the serum amyl-ase activity in the acute phase SAP group was higher than that in the MAP group ,and the difference was statistically significant (P<0 .05) .The relative expressions of serum miR-216a in MAP group and SAP group in acute stage were significantly higher than those in convalescence in these groups and the control group (P<0 .05) ,and the relative expressions of serum miR-216a in SAP group was higher than that in the MAP group ,and the difference was statistically significant (P<0 .05) .The miR-216a expression was positively correlated with Ranson score ,APACHE score and MCTSI score (r=0 .667 ,P<0 .05 ;r=0 .396 ,P<0 .05 ,and r=0 .648 ,P<0 .05) .Conclusion The expression level of serum miR-216a of patients with AP was significantly higher than that of healthy people ,and the expression level of serum miR-216a was positively correlated with the severity of AP ,which was useful for the diagnosis and prognosis of SAP .
