Safety and Feasibility of Thallium-201 Myocardial SPECT with Intravenous Infusion of Disodium Sdenosine Trophosphate ( ATP ) in the Diagnosis of Coronary Artery disease.
- Author:
Moon Sun PAI
;
Chan H PARK
;
Seok NAM
;
Yoon Won KIM
;
Han Soo KIM
- Publication Type:Original Article
- Keywords:
thallium-201;
disodium adenosine triphosphate;
coronary artery disease
- MeSH:
Adenosine Triphosphate*;
Aminophylline;
Chest Pain;
Coronary Angiography;
Coronary Artery Disease*;
Coronary Vessels*;
Diagnosis*;
Dyspnea;
Flushing;
Follow-Up Studies;
Half-Life;
Headache;
Humans;
Infusions, Intravenous*;
Perfusion Imaging;
Sensitivity and Specificity;
Tomography, Emission-Computed, Single-Photon*
- From:Korean Journal of Nuclear Medicine
1998;32(3):250-258
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: ATP (adenosine triphosphate) is a potent coronary vasodilator with a rapid onset of action and a very short half-life. Myocardial perfusion scintigraphy with intravenous ATP has not yet been sufficiently proven in the diagnosis, follow-up, and risk stratification of coronary artery disease. The purpose of this study was to evaluate the safety, feasibility and diagnostic accuracy of pharmacologic stress thallium-201 myocardial SPECT using an intravenous ATP infusion in patients with suspected coronary artery disease. MATERIALS AND METHODS: Thalliurn-201 myocardial SPECT in 319 patients with suspected coronary artery disease were performed after the infusion of ATP (0.08 mg/kg/min for 6 rnin). The adverse effects were carefully monitored. Coronary angiography was also performed within 3 weeks. RESULTS: Although 76.5% of the patients had sorne adverse effects, they were transient, mild, and well tolerated. In all patients, the ATP infusion protocol was completed and only 2 patients required aminophylline. The adverse effects were dyspnea in 63%, headache in 31%, flushing in 21%, chest pain in 14% and abdominal discomfort in 5% of the patients. The sensitivity and specificity were 80% and 90% respectively. CONCLUSION: Thallium-201 myocardial SPECT after 6 min-infusion of ATP at a rate of 0.08 mg/kg/min is safe and has a diagnostic value in detecting coronary artery disease.
