IL-25 and allergic airway inflammation
10.11855/j.issn.0577-7402.2017.11.02
- VernacularTitle:IL-25与变态反应性气道炎症
- Author:
xin Hai HE
1
;
yu Hai HONG
Author Information
1. 519020广东珠海,中山大学附属第五医院耳鼻咽喉头颈外科
- Keywords:
airway inflammation;
allergy and immunology;
interleukin-25;
receptors,interleukin-25
- From:
Medical Journal of Chinese People's Liberation Army
2017;42(11):945-950
- CountryChina
- Language:Chinese
-
Abstract:
Allergic airway inflammation is manifested as infiltration of CD4+ T cells and eosinophils in the airway,increased secretion of mucus,airway hyper-reactivity and airway remodeling.IL-25 is a member of the IL-17 family,which can promote and exacerbate Th2 cytokine-mediated airway inflammation after binding to its receptor IL-17RB.The increased IL-25 can induce the secretion of Th2 cytokines,including IL-4,IL-5 and IL-13,which may result in the local infiltration of eosinophils,airway hyperreactivity and therefore the injury of airway.As IL-25 plays an important role in allergic airway inflammation,the present paper would focus on the relationship between IL-25 and allergic airway inflammation.
